Learn what "what's going on with you" means, when people say it, and how to use it naturally in English.

It means the speaker wants to know why the other person is acting strangely or upset.
From The Billionaire’S Lost Love, Episode 24
Someone asks what is wrong with the other person.
Use this when you notice someone seems off or upset. It can sound caring, but tone matters because it may also sound confrontational.
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