Learn what "what have they done to you" means, when people say it, and how to use it naturally in English.

It means the speaker wants to know who harmed, pressured, or affected the other person.
From I'M Obsessed With My Boss Part Ii, Episode 50
Someone is asking what was done to another person because they sound hurt or changed.
Use this when someone seems hurt and you want to ask what happened. It can sound emotional and protective, but also accusatory if said sharply.
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