Learn what "what does this have to do with anything" means, when people say it, and how to use it naturally in English.

It means the speaker thinks the point being raised is irrelevant.
From On One Condition, Episode 18
The speaker wants to know why the other person is bringing up something that seems unrelated.
Use it when you want to challenge a comment or question in an argument. It can sound impatient or dismissive.
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