Learn what "what does that have to do with anything" means, when people say it, and how to use it naturally in English.

This means the speaker thinks the other person's comment is unrelated and not important to the current issue.
From The Mistress Trap, Episode 21
The speaker rejects the other person's point as irrelevant.
Use it in arguments or debates when someone brings up something off-topic. It can sound sharp or impatient, so avoid it in polite situations.
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