Learn what "what are you talking about" means, when people say it, and how to use it naturally in English.

It means the speaker does not understand or believes the other person is saying something strange or untrue.
From Runaway Bride, Episode 9
Someone is reacting with confusion to what another person just said.
Use this in conversation when you need clarification or want to challenge someone's statement. It can sound defensive in an argument.
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