Learn what "she had a real beef with you" means, when people say it, and how to use it naturally in English.

This means she had a serious problem with you or was angry at you.
From The Dumb Billionaire Heiress In Love Part Ii, Episode 44
The speaker is saying another person had a strong grudge against someone.
Use this in informal conversation about conflict or resentment. It is casual and can sound rude or dismissive in formal situations.
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